国际麻醉学与复苏杂志   2023, Issue (5): 9-9
    
中脑星形胶质细胞源性神经营养因子在脑缺血再灌注损伤中的作用
周道英, 李娟1()
1.中国科学技术大学附属第一医院(安徽省立医院)
Role of a mesencephalic astrocyte‑derived neurotrophic factor in cerebral ischemia reperfusion injury
 全文:
摘要：

中脑星形胶质细胞源性神经营养因子（mesencephalic astrocyte‑derived neurotrophic factor， MANF）是一种进化保守的神经营养因子，大量研究表明MANF在脑缺血再灌注损伤（cerebral ischemia reperfusion injury, CIRI）中发挥重大的调节作用，通过参与内质网应激（endoplasmic reticulum stress, ERS）抑制炎症反应和细胞凋亡等，缓解CIRI。文章综述了MANF的功能以及在CIRI中的作用及其可能的作用机制，以期为进一步探寻CIRI的防治措施提供新方向。
关键词： 缺血再灌注损伤;中脑星形胶质细胞源性神经营养因子;内质网应激;炎症反应;凋亡;脑
Abstract:

Mesencephalic astrocyte‑derived neurotrophic factor (MANF) is an evolutionarily conserved neurotrophic factor. A large number of studies have shown that MANF plays an important role in cerebral ischemia‑reperfusion injury (CIRI). By participating in endoplasmic reticulum stress (ERS), inhibiting the inflammatory response and cell apoptosis, it alleviates CIRI. This article reviews the function of MANF, its effect, and its possible mechanism in CIRI, to provide a new direction for further exploring the prevention and treatment measures of CIRI.
Key words: Ischemia reperfusion injury; Mesencephalic astrocyte‑derived neurotrophic factor; Endoplasmic reticulum stress; Inflammatory response; Apoptosis; Cerebrum