To compare the clinical efficacy of corticosteroid injection combined with electroacupuncture in the treatment of osteoarthritis of ankle joint (AOA). Methods From September 2022 to December 2022, 60 patients with AOA who were treated in our department were randomly divided into control group and test group according to 1:1, with 30 patients in each group. Both groups were treated with corticosteroid injection (CI), and the experimental group was treated with myofascial trigger point (MTrP) acupuncture on this basis. Compare the visual analog scale (VAS), ankle hindfoot scale (AOFAS), active ankle range of motion (AROM), and short from health survey (SF-36) of the two groups, and record the number of people who used the remedy analgesic drug aminophentramadol during hospitalization. Results Compared with before treatment, VAS, AOFAS, AROM and SF-36 in the two groups were improved (P0.05); Compared with the control group, the VAS score of the test group decreased more significantly at 3 months after treatment (P0.05), the AOFAS score increased more significantly at 1 day, 1 week, 1 month and 3 months after treatment (P0.05), and the SF-36 score improved more significantly at 3 months after treatment (P0.05). Conclusion Corticosteroid injection combined with electroacupuncture for the treatment of ankle osteoarthritis has better efficacy and more lasting improvement in ankle pain relief, functional activity, and long-term quality of life than simple corticosteroid injection therapy.