Objective To investigate whether stellate ganglion block (SGB) can reduce the use of intraoperative antiarrhythmic drugs in off‑pump coronary artery bypass grafting (OPCABG), improve the flow of bridging vessels, and reduce the incidence of postoperative complications. Methods A total of 120 patients who received elective OPCABG were selected. According to the presence of left stellate ganglion block (LSGB) before surgery, they were divided into two groups (n=60): a LSGB group and a control (C) group. Patients in the LSGB group received LSGB before anesthesia induction, while those in the C group did not receive LSGB. Both groups underwent the same procedures for anesthesia induction and maintenance. Then, their age, BMI, left ventricular ejection fractions (LVEF), operation time, and the number of coronary artery bypass grafts were recorded. Furthermore, the consumption of lidocaine, amiodarone, cedilanid, esmolol, and other antiarrhythmic drugs during the operation, the flow of bridging vessels, and the incidence of postoperative complications were recorded. Results There was no statistical difference in age, BMI, LVEF, operation time, and the number of coronary artery bypass grafts between the two groups (P>0.05). Compared with the LSGB group, the utilization rates of lidocaine and esmolol in the C group significantly increased (P<0.05). There was no statistical difference in the utilization rate of amiodarone and cedilanid between the two groups (P>0.05). The flow of bridging vessels in the left internal mammary artery‑anterior descending branch, the great saphenous vein-posterior descending branch and the great saphenous vein-circumflex branch in the LSGB group was higher than that in the C group (P<0.05), while no statistical difference was found as to the flow of bridging vessels in the great saphenous vein-anterior descending branch, the great saphenous vein-diagonal branch and the great saphenous vein-right coronary artery between the two groups (P>0.05). There was no statistical difference in the incidences of postoperative pulmonary infection, renal insufficiency, respiratory failure, pleural effusion, poor wound healing, cerebral infarction, acute heart failure, and other complications between the two groups (P>0.05). Conclusions General anesthesia combined with LSGB can significantly reduce the consumption of intraoperative antiarrhythmic drugs, slow down the heart rate and improve the flow of bridging vessels, but does not affect the incidence of postoperative complications.