Objective To investigate the effect of general anesthesia using intravenous drug sequential induction combined with laryngeal mask airway on intraocular pressure (IOP) during pediatric external eye surgery, and to explore the influencing factors on IOP before and after the intravenous anesthesia induction period. Methods A total of 69 children aged 2−14 years without history of glaucoma were selected from December 2021 to March 2022. They were anesthetized by intravenous administration of propofol, sufentanil, midazolam, rocuronium bromide, and laryngeal mask ventilation under general anesthesia. The intraocular pressure before and after intraoperative eyes induction, before and after non‑intraoperative eyes induction and before extubation were recorded. To investigate the effects of weight, sex, age, height, and dosage of induction drugs on IOP before and after induction. Results The IOP of the operated and non‑operated eyes after induction was lower than that before induction, and the difference was statistically significant (P<0.05). There was a significant difference in IOP between non‑operative eyes before induction and after extubation (P<0.05). The IOP difference between the non‑operative eyes after induction and after extubation had little change， also, there was no statistical difference (P>0.05). Gender, age, height, weight, induction drug dosage, and other factors had no significant difference on the IOP difference between the operated and non‑operated eyes before and after induction (P>0.05). Conclusions General anesthesia by intravenous induction of propofol, sufentanil, midazolam, and rocuronium bromide combined with laryngeal mask ventilation reduces IOP in children undergoing external surgery.