Impact of postoperative delirium on postoperative neurocognitive disorder: a meta-analysis Zhang Shaolan1, Tang Siwei2, Huang huawei1, Zhang guobin3, Li haoyi3, Wu Lei1; Shi Guangzhi1 1Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing 100000, China; 2 Department of Neurosurgery ,Qingdao Municipal Hospital (Group), Qingdao 266000, China; 3Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing100000, China. Corresponding author: Shi Guangzhi, Email: shigzh0669@163.com 【Abstract】Objective To explore the relationship between postoperative delirium (POD) and postoperative neurocognitive disorder (p-NCD). Methods Studies on the correlation between POD and cognitive dysfunction from the database construction to January 1, 2022 were searched systematically. CMA V3 statistical software was used for Meta-analysis, and the Odds ratio and 95% CI were calculated by random effect model. Publication bias was evaluated by funnel plot and Egger's test. Results A total of 11 studies were included, with a total of 5326 patients that were older than 60 years. Meta-analysis showed that postoperative delirium was significantly associated with p-NCD (OR=2.308 95% CI 1.555-3.426, P0.001). Subgroup analysis indicated that the episode of POD was correlated with decreased attention (OR=1.671，95% CI 1.044 - 2.674, P0.05) and impaired memory postoperatively (OR=1.483，95% CI 1.115-1.974, P0.05). In addition, our results showed cognitive trajectory decline significantly associated with POD within 1 year. Conclusions POD is closely related to postoperative neurocognitive dysfunction. 【Key words】Postoperative delirium； Postoperative neurocognitive disorder；Dynamic risk trajectory；Meta-analysis Fund program: Science and Technology Planning Project of Beijing of China (Z201100005520039)