The specificity of the brachial plexus nerve pathway allows for a variety of approaches to the brachial plexus block. In recent years, with the in‑depth study of human anatomy, a new type of approach to the brachial plexus nerve block has appeared, which is the cribriform interspace approach. The bundles of the brachial plexus nerves at the costoclavicular space converge with each other and are located lateral to the axillary artery, with low anatomical variability. The brachial plexus nerve block at the costoclavicular space is simple to perform and requires less volume of local anesthetic, which has been increasingly used in upper extremity surgery. This paper reviews the anatomy, technique, volume, and concentration of local anesthetic, and the advantages and shortcomings of brachial plexus nerve block at the costoclavicular space, with a view to providing reference for clinical practice.