Objective To investigate the effect of transcutaneous electric point stimulation (TEAS) on postoperative fatigue (POF) in patients undergoing laparoscopic radical gastric cancer. Methods A total of 94 patients who underwent elective laparoscopic radical gastric cancer surgery were selected. According to the random number table method, they were divided into two groups (n=47): a TEAS group (group T) and a blank control group (group C). After induction of anesthesia, transcutaneous electric stimulation was applied to the bilateral Neiguan point (PC6), Zusanli point (ST36) and Shangjuxu point (ST37) until the end of the operation in group T; in group C, electrode pads were applied to the same acupuncture points, which were only fixed but not electrically stimulated. Before surgery, all the patients were evaluated for nutritional risk screening, using the Nutritional Risk Screening Scale‑2002 (NRS‑2002). The Identity-Consequence Fatigue Scale (ICFS) scores and the Hospital Anxiety and Depression Scale (HADS) scores were recorded for all patients one day before surgery and on postoperative 1, 3, and 7 days. The Visual Analogue Scale (VAS) scores were recorded when the patients left from the postanesthesia care unit (PACU), and on postoperative 1, 3, and 7 days. The levels of hemoglobin (Hb), albumin and C‑reactive protein (CRP) and white blood cell (WBC) count were recorded. The dosage of intraoperative anesthetic drugs, vasoactive drugs and postoperative analgesic drugs were recorded. Meanwhile, the length of PACU stay, the duration of anesthesia and surgery, blood transfusion, fluid intake and output, the time of first off-bed activity after surgery, the time of exhaustion, the length of postoperative hospitalization stay and the incidences of postoperative complications were also recorded. Results Compared with group C, patients in group T had significantly reduced ICFS scores on postoperative day 1 (P<0.05), with an remarkably increased proportion of patients with mild anxiety and depression as well as a obviously decreased proportion of patients with moderate and severe anxiety and depression on postoperative day 1 (P<0.05); they also showed significant increases in the proportion of patients with mild pain and significant decreases in the proportion of patients with moderate pain when the patients left from PACU and on postoperative day 1. Meanwhile, the WBC count on postoperative day 1 and the levels of CRP on postoperative days 1 and 3 significantly reduced in group T, compared with those in group C (P<0.05). The length of PACU stay and the dosages of propofol and remifentanil during operation in group T were significantly lower than those in group C (P<0.05). There was no statistical difference in the time of first off-bed activity after surgery, the time of exhaustion, the length of postoperative hospitalization stay, the incidence of complications and the consumption of remedial drugs between the two groups (P>0.05). Conclusions TEAS can reduce the dosages of intraoperative anesthetic drugs, alleviate anxiety and depression, relieve postoperative pain, reduce leukocytes and CRP levels and relieve postoperative fatigue in patients undergoing laparoscopic radical gastric cancer.