国际麻醉学与复苏杂志   2023, Issue (10): 9-9
    
环泊酚在临床麻醉中的应用研究进展
陈靖, 朱芸燕, 张传武, 曾名望, 杨超, 张文福, 梁伟东1()
1.赣南医学院第一附属医院
Research progress on the application of ciprofol in clinical anesthesia
 全文:
摘要:

环泊酚是一种新型麻醉镇静药物,具有两快五少的临床特点,即:起效快;苏醒快;更少用量,安全窗更宽;更少呼吸抑制;更少心血管不良事件,循环稳定;更少注射痛;更少脂质输入。与丙泊酚相比,环泊酚较少发生呼吸抑制及心血管不良事件,它为临床老年患者及危重患者的平稳镇静麻醉提供更好的选择,成为较理想的镇静药物。本文主要就环泊酚的作用机制、药效与药代动力学、镇静药物对比分析、临床应用研究进展等进行综述,旨在为其临床应用提供理论依据。

关键词: 环泊酚;γ‐氨基丁酸受体;镇静;麻醉
Abstract:

Ciprofol is a new type of anesthetic sedative drug,with two quick and five low clinical characteristics,namely:quick onset;wake up quickly;less usage,wider safety window;less respiratory depression;fewer adverse cardiovascular events and stable circulation;less injuction pain and less lipid input。Compared with propofol,ciprofol has less respiratory depression and cardiovascular adverse events。It is an idea sedative drug to provide a better choice for the stable sedation and anesthesia of clinical elderly patients and critically ill patients.In this papper,the mechanism of action,pharmacokinetics,comparative analysis of drugs and clinical application of ciprofol were reviewed,aiming to provide theoretical basis for clinical application。

Key words: Ciprofol;Gamma- aminobutyric acid (GABA) receptor;Sedation;Anaesthesia