Objective To investigate the postoperative analgesic effect of parecoxib following laparoscopic cholecystectomy when local anesthetics was infilltrated at incision site. Methods Fifty patients undergoing laparoscopic cholecystectomy were randomized, double-blind divided into two groups: patients in the experimental group received intravenous parecoxib 40mg 10 minutes before operation, and patients in the control group received intravenous physiological saline in same volume. All the patients received incision infiltration with 0.5% bupivacaine 8ml at navel before the operations. The observation time points included T1(departure from the PACU), T2( 5 hours after the operation) and T3(the morning of postoprative day 1). VAS values, additional requirement of opioids analgesia, the rate of satisfactory with analgesia quality and sleep quality was compared between two groups. Results: The VAS values in the experimental group were significantly lower than in the control group at T1 and T2 (T1：1.6±0.5 vs 3.6±0.7，T2：1.8±0.6 vs 3.5±0.9，P<0.05), while VAS was lower in the experimental group at T3, but the difference had no Statistical significance . The rate of satisfactory with analgesia and sleep quality in the experimental group was significantly higher than in the control group. Conclusion Paricoxib combined with incision infiltration can significantly relieve the postoperative pain in the patients receiving laparoscopic cholecystectomy.