Objective To examine recovery profile and haemodynamic differences using remifentanil infusion with either propofol target controlled infusion system or sevoflurane inhalation for laparoscopic cholecystectomy. Methods Forty-eight adult patients，ASAⅠ-Ⅱgrade，undergoing elective laparoscopic cholecystectomy were randomly divided into two groups（n=24）. Group RP received propofol target controlled infusion system and remifentanil; Group RS received sevoflurane and remifentanil for maintenance of anaesthesia. The amount of narcotic medication during the oporation, mean arterial pressure（MAP）and heart rate（HR）at each time point during anesthesia and awake time for patients after surgery of the two grous were recorded. Results No statistically significant differences between the two groups with tegards to the haemodynamic changes（P>0.05）. Recovery times were considerably shorter after remifentanil-sevoflurane（7.0±3.4）min in comparison with remifentanil-propofol（13.1±7.8）min target controlled infusion system group（P<0.01）. Conclusion Remifentanil-propofol and sevoflurane-remifentanil combinations provide a similar adequate haemodynamic stability. However, sevoflurane-remifentanil gives a faster recovery compared with propofol target controlled infusion system with remifentanil for laparoscopic cholecystectomy.