Ventricular remodeling after acute myocardial infarction is a common physiopathologic process in clinics, and the extent of ventricular remodeling is closely related to cardiac function and prognosis of patients. At present,the mechanism of Proto-oncogene induced ventricular remodeling after acute myocardial infarction has been recognized. Therefore , regulating the expression of Proto-oncogene provide us a new therapeutic way of ventricular remodeling.