Heart is the power source of hemocircular, and the mitochondria of cadiocyte provided energy for cytolergy in this process. The function of mitochondria were happened to anomalism in the process of ischemic-reperfusion, and the open of mitochondrial permeability transition pore(MPTP)is lead to irreversible cell injury. Therefor, inhibited the open of MPTP, protected physiological function of mitochondrial is latest hot spot of myocardial preservation investigation. This review articles is refer to the study current situation of MPTP.