Background Injection pain is a common adverse effect of propofol , not only enhances the tension of the patient ,but also breaks the smooth of the anesthesia. Objective We summarize the strategies of propofol in reducing injection pain. Content Mechanism involves stabilizing the cell membrane and changing the water phase concentration of propofol. Local or general anesthetics are applied. Dose or interval of the premedication differs. Combing medicine with physical method such as a tourniquet appears more effective. Trend Numerous methods to reduce propofol injection pain exhibit positive effects, but it still need to be improved. A simple and convenient way should be adopted in clinical use.