Objectives To observe the clinical value of continuous central venous pressure monitoring combined with the plasma electrolyte, osmotic pressure and adverse event at different examining times in early diagnosis of TURP syndrome. Materials and methods Forty patients undergoing TURP were randomly divided into observation group and control group. As the control group,20 patients undergoing TURP without CVP monitoring．If CVP increased more than 5cmH20 or CVP was more than 20 cmH20, rapid iv 40 mg dose of lasix (a loop diuretics). If the patient displayed agitation in the control group, detect serum sodium as soon as possible . While the results showed the serum Na+ was reduced, the same management was executed as in the observation group. Results Compared with preoperation , the changes of serum Sodium had the trend of declining in control groups, In observation group, the CVP had the tendency of ascent in the progress of operation, The CVP is more than 12cmH2O or increased 5cmH2O than that of preoperative in five patients, and run up to 20cmH2O in one patient in 90 min after the operation ( perfusion fluid about 20000-25000 ml ) , rapid intravenous injected 10-20 mg lasix (a loop diuretics), then we found that CVP returned to the preoperative level. All of the five patients whose CVP increased had a decreased serum sodium in different degrees. 1 case of TURS occurred in control group, while none occurred in observation group.Conclusions The CVP had the tendency of ascent in the progress of TURP operation. , CVP reflected the changes of blood volume re-back to heart. If the CVP increased 5cmH2O or the total greater than 12 cmH2O,early changes TURS was prevented effectively through diureticing at early stage. Continuous monitoring of CVP had certain clinical significance in early TURP diagnosis, as the changes in blood volume induced by absorption of rinse solution were earlier than the changes in serum Sodium.