LipidRescue™ resuscitation refers to the use of an intravascular infusion of a lipid emulsion to treat local anesthetic systemic toxicity. More recently, LipidRescue™ has been proposed (in articles in the ER literature and elsewhere) as a treatment modality for poisoning or overdose by lipophilic agents in general. The method is of milestone meaning for treatment of lipophilic agents overdose.Further work is required to explore mechanism of lipid emulsion on resuscitation of local anesthetic toxicity and optimize the treatment regimens with respect to efficacy and safety of lipid rescue.