Fospropofol disodium(Fospropofol,FPD),a new sedative/hypnotic drug,is a water-soluble prodrug of propofol,metabolized in vivo to produce liberated active propofol which performs sedative function.As its hydrolytic action in vivo,the pharmacokinetics and pharmacodynamics of fospropofol disodium are significantly differ from lipid-emulsion-based propofol. Clinical trials of fospropofol disodium can be safe and effective for the sedation of colonoscopy, flexible bronchoscopy and minor procedures. With further progress, fospropofol disodium will have a broader clinical application.