国际麻醉学与复苏杂志   2011, Issue (6): 8-8
    
瑞芬太尼、芬太尼对过度肥胖患者麻醉效果及麻醉复苏质量的影响
王胜, 司马靓杰, 郭素香1()
1.新疆石河子大学医学院第一附属医院麻醉科
the effect on remifentanil, fentanyl anaesthesia and the quality of anesthesia recovery in obese patients
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摘要：

摘要：目的：本实验旨在探讨芬太尼和瑞芬太尼对于肥胖患者全身麻醉及复苏的影响，探索联合应用两种药物的可行性，并找到较为可行的联合方式。方法：随机将实施全身麻醉的肥胖患者分为4组，每组20人，分别是F组，R组，RF1组和RF2 组，比较四组患者的全身麻醉中的安全性和有效性以及麻醉后的复苏质量。结果： 麻醉诱导时R组和RF2组在预防插管等刺激所引起的MAP和HR变化较小（P<0.05）。麻醉后R组和RF2 组拔管时间和睁眼时间及定向力恢复时间较短（P<0.05）和OAA/S评分较小（P<0.05），但是R组的停药后1和3小时的VAS评分较差（P<0.05），RF2组和F组评分差异无统计学意义（P>0.05）。结论：以RF2组方式联合应用芬太尼和瑞芬太尼不仅在全身麻醉中安全有效，而复苏质量较好。
关键词： 关键词：芬太尼、瑞芬太尼、肥胖患者、麻醉效果、复苏质量
Abstract:

Abstract: objective: this experiment is aimed to study the effect of fentanyl and remifentanil in general anesthesia and recovery in obese patients and explore the influence of combined use of two drugs, and find the feasibility of feasible combinations. Methods: 80 obese patients exerted to general anesthesia are randomly divided into four groups (n= 20); group F, group R, group RF1 and group RF2, the safety and efficacy in general anesthesia and the recovery quality post anaesthesia were investigated. Results: MAP and HR have no significant changes (P < 0.05) in group R and group RF2 in induction of general anesthesia. Decannulation time , open eyes time and directional power recovery after anesthesia in group R and group RF2 are in a relatively short time (P < 0.05) and OAA/S score is smaller (P < 0.05), but 1 and 3 hours after discontinuation is poor in VAS score (P < 0.05) in group R, Conclusion: combined use of fentanyl and remifentanil as group RF2 is not only safe and effective in general anesthesia, and achieves high quality of recovery.
Key words: Keywords: remifentanil fentanyl obese patients anesthesia efficacy quality of anesthesia recovery