Background　Tissue acidosis is a common pathological feature of many painful conditions including inflammation， ischemia and bone destruction. Acid sensing ion channels （ASICs） are excitatory cation channels directly activated by extracellular protons that are expressed in the nervous system， and mediate nociception indcued by tissue acidosis.　Objective　It will provide a new approach to take ASICs for pain treatment targets.　Content　The studies of ASICs in mediating nociception associated with tissue acidosis is reviewed.　Trend　Recent studies show that ASICs play a key role in mediating nociception associated with tissue acidosis， and it will provide a novel approach for development new analgesic drugs and pain treatment targeted ASICs.