Background Chronic persistent pain is probably the most commonindicator for patients seeking therapy in clinics. The effective therapy for chronic persistent pain is emphasized much more than before. Objective To introduce the biological characteristics of basic fibroblast growth factor (FGF-2) and its functions in regulations of chronic pain. Content Astrocytes plays an important role in chronic pain. FGF-2 is a well-known activator of astrocytes, which increased in spinal cord during chronic pain. Trend How FGF-2 regulates the pain signal pathway needs to be further explored. The process of pain is composed of multiple cells and factors and their interaction mechanism needs further research.