【Abstract】 Background Obese people, who is increasing in recent years, has higher probability of surgery because of obesity itself and/or its complications. Its perioperative management may be a major challenge for anesthesiologists. Combined use of rapid-onset, short-acting narcotic drugs is the development trend of total intravenous anesthesia. The co-administration of propofol and remifentanil has many advantages in short surgeries. Target Controlled Infusion(TCI) systems can administer drugs at a specific concentration, ensuring a more accurate and stable target concentration. Objective To investigate the feasibility and prospects of TCI with propofol and remifentanil in obese subjects. Content The effects of obesity on intravenous anesthetics were elaborated. The feasibility of TCI with propofol and remifentanil in obese subjects was analyzed according to the recently published literatures. Trend Pharmacodynamic models for TCI systems in obese patients are expected in clinic.