【Abstract】Background It has been proved that sepsis is the systemic inflammatory response syndrome caused by infection factors. In the course of sepsis, the organism and pathogen interactions lead to pro-inflammatory and anti-inflammatory imbalance. Purpose Peroxisome proliferator activated receptor gamma (PPAR-γ) is a ligand activated nuclear receptor transcription factor. Bound with ligand, it plays an important role in inflammatory signal transcription pathway. Through inhibition of the inflammatory reaction, PPAR-γ has a protective effect in sepsis. Therefore, it is important to know about the present status and probable future trends of PPAR-γ and sepsis. Content PPAR-γ plays an important role in many aspects, for example, ease of autoimmune diseases, inflammatory, inhibition of hypersensitivity, antitumor and allograft rejection. According to PPAR-γ in the pathogenesis of sepsis and therapeutic study, we made this review. Trend Because of structure and functional complexity, the mechanism of PPAR-γ is unclear. It is thought that it will open new treatment strategy with the in-depth research of PPAR-γ.