【Abstracts】 Background The non-depolarizing muscular relaxants (NDMRs) are used widely in genegral anesthesia and intensive care. The muscle-type nicotinic acetylcholine receptor (m-nAChR) site on the postsynaptic membrane of neuromuscular junctions (NMJs) is the target location of the NDMRs.Many factors can affect the potency of NDMRs. Objective We investigate the factors of changing of the m-nAchRs which can affect the the potency of NDMRs to provide some advice for clinical anesthetic medication. Content All the changes of the quality and quantity of m-nAchR, including the quantity, density, desensitization, phosphorylation,conformation and affinity of the m-nAchR as well as the state of opening or closing about the ion channels of the m-nAchR, the effect of cholesterin、adenosine triphosphate (ATP) and so on, will affect the potency of NDMRs. Trend Hope to provide some opinions for investigatng the mechanisms which may affect the potency of NDMRs.