国际麻醉学与复苏杂志   2013, Issue (2): 2-2
    
高血压患者围术期压力反射敏感性的初步研究
黄丹, 陈杰, 杜唯佳, 王祥瑞1()
1.上海交通大学医学院附属仁济医院
Preliminary analysis on perioperative baroreflex sensitivity in patients with hypertension
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摘要:

目的 探讨高血压患者围术期压力反射敏感性(baroreflex sensitivity, BRS)的变化规律及自主神经功能状态。 方法 采用有创动脉测压测定48例高血压患者(包括24例经治疗的患者及24例未经治疗的患者)及48例非高血压患者在给予硝酸甘油前后的血压、心率变化,根据Robert公式计算出BRS值。 结果 高血压患者术前BRS值(3.3±2.0)、术中的BRS值(1.7±1.1)明显低于非高血压患者[术前、术中分别是(5.7±4.1)和(3.3±3.1)](P<0.01),未经治疗的高血压患者术前BRS值(2.1±1.3)、术中BRS值(1.5±0.9)、术毕时的BRS值(1.4±1.3)明显低于经治疗的高血压患者[术前、术中、术毕分别是(5.3±1.8)、(2.0±1.8)、(1.8±1.2)](P<0.01)。 结论 高血压患者围术期的自主神经功能明显受损,经治疗的高血压患者围术期的自主神经功能有所改善。

关键词: 高血压,围术期,压力反射敏感性
Abstract:

Objective To analyze perioperative baroreflex sensitivity (BRS) in patients with hypertention and the autonomic nerve activity. Methods Blood pressure and heart rate before and after injection nitroglycerin were measured in patients with hypertension or without (n=48 including 24 undergoing treatment patients). BRS was calculated according to Robert formula. Results BRS Baseline(3.3±2.0) and BRS intraoperative(1.7±1.1) in patients with hypertension were obviously lower than those in non-hypertension patients [(5.7±4.1), (3.3±3.1) respectively, P<0.01]. BRS Baseline(2.1±1.3), BRS intraoperative(1.5±0.9) and BRS postoperative(1.4±1.3) in patients without treatment were lower than those in patients undergoing treatment [(5.3±1.8), (2.0±1.8), (1.8±1.2) respectively, P<0.01]. Conclusions The perioperative autonomic nerve function is significantly impaired in patients with hypertension. And the impaired autonomic can be improved by treatment.

Key words: Hypertension; Perioperative; Baroreflex sensitivity