Abstract : Background: Pulmonary embolism is one of the common complication during perioperative period. Because its incidence and mortality rates are high, it seriously threatened the life safety of surgery patients. Objective: To improve the prognosis of perioperative patients with surgery, reduce the incidence of perioperative pulmonary embolism, the paper review the clinical prevention of perioperative pulmonary embolism. Content: Mainly aimed at the risk factors of perioperative pulmonary embolism, discusses the controversy and progress of clinical effective anticoagulant and interventional preventive measures at home and abroad at present, and how to optimize implementation to make the incidence of perioperative pulmonary embolism minimize. Trend : Taking comprehensive prevention measures that give priority to anticoagulation drugs and aid by mechanical and interventional anticoagulation can effectively reduce the incidence of perioperative pulmonary