Background Necroptosis is a programmed cell death and has been a focus of many research fields. Objective To provide some useful information for related researches, this review summarized the receptors, signaling pathway and the relationship among necroptosis-related molecules. Content Necroptosis is mediated by death receptor ligation when apoptotic pathway is inhibited.The complex Ⅱ,which is formed by increasing aggregation of, unbiqutinated receptor-interact protein 1（RIP1） and the interaction between RIP1and receptor-interact protein 3（RIP3） are the key elements for necroptosis signaling pathway activation. Necrostatin-1 blocks death receptor-induced necroptosis as an allosteric RIP kinase inhibitor. Necroptosis requires energy. While metabolism increases, reactive oxygen species (ROS) deriveing from mitochondriacan acts as the downstream transduction signal involving in tumor necrosis factor (TNF) mediated necroptosis. Trend Necroptosis contributes to the occurrence and development of multiple diseases such as inflammation and trauma and are of profound significance for directing clinical therapy.