Objective To investigate the application of general anesthesia combined with brachial plexus block in shoulder arthroscopy. Methods Forty-four patients (ASA Ⅰor Ⅱ, aged 35-65 yrs, undergoing shoulder arthroscopy) were randomized into group A and B (n=22,each). While both groups having received inhalation-intravenous general anesthesia (GA), group B also received ultrasound-guided interscalene brachial plexus block with 0.2% ropivacaine 20ml before GA. The HR, SBP, DBP, MAP and SpO2 at entering operation room, before skin incision, at skin incision, 30min, 60min and 90min after skin incision, and 30min after tracheal extubation，the use of sufentanyl, rocuronium, isosorbide dinitrate and esmolol，and SaO2, PaO2 and PaCO2 before and after surgery，and the spontaneous respiration regaining time, tracheal extubation time and fully consciousness regaining time，and the visual analog scale (VAS) of pain, analgesics application and complications in the PACU were recorded. Results The HR and MAP at skin incision, and the MAC of sevoflurane and dosage per weight of sufentanyl in group A and B were 68±11 and 63±7 bpm, 85.8±15.0 and 68.8±10.1mmHg, 1.28±0.21 and 1.08±0.20MAC, 0.54±0.08 and 0.34±0.06ug/kg , respectively (P<0.001). The cases that needed esmolol or isosorbide dinitrate, the post-operation PaCO2 and the tracheal extubation time in group A and B were 12 and 2 cases, 13±10 and 7±4min, 44±3 and 42±3mmHg, respectively（P<0.05）. The pain VAS of group A and B were 4±2 and 0±2, respectively (P<0.001). There were no significant statistic differences between the two groups in relevant complications（P>0.05）. Conclusions Brachial plexus block combined with general anesthesia enhances the anesthesia quality in shoulder arthroscopy, which not only reduces the fluctuation of blood pressure, decreases the use of narcotic analgesics and short-acting antihypertensive agents, but also shortens the tracheal extubation time , and has short-time postoperative analgesic effect and no severe complications.