Objectives: To evaluate the efficacy and safety of sodium potassium magnesium calcium and glucose injection (Le Jia®) comparing sodium lactated ringer’s solution for burn resuscitation. Methods: 199 burned patients, who met the criterion and were performed fluid resuscitation during the first 6 hours after injury, were enrolled in this study and assigned randomly either to the sodium potassium magnesium calcium and glucose injection group (test group) or to the sodium lactated ringer’s group (control group). Before the fluid resuscitation according to 1970 National Conference of Burn Injuries formula, the clinical index such as routine blood count, liver and kidney functions, blood biochemistry and coagulation function were detected. The hemodynamic index, arterial blood gas and serum glucose levels were monitored during fluid infusion, and all blood lab index were detected at the end of the first and second 24h after resuscitation beginning, respectively. The efficacy index were the changes of serum electrolyte, arterial blood lactate, blood gas and serum glucose levels after resuscitation of two different electrolyte solution, and the safety index were the incidence and specific situation of adverse drug reaction. Results: Comprehensive analysis was performed from the aspects of maintaining of serum electrolyte and acid-base equilibrium and changes of blood lactate and glucose levels. No statistically significant difference was found between the two groups. In safety evaluation, safe cases in test group were 99 (100%) as well as in control group. No statistically significant difference was found in safety evaluation. Conclusions: Sodium potassium magnesium calcium and glucose injection (Le Jia®) has the comparative efficacy and safety to sodium lactated ringer’s solution, the most commonly used in clinic for burn resuscitation.