Background Postoperative Cognitive Dysfunction（postoperative cognitive dysfunction，POCD）is a common complication after surgery, It not only results in delayed recovery, increasing medical expenses but also affects the quality of patients’ life badly .The results of the present study show that POCD may be the result of several mechanisms, which are mainly associated with the cholinergic system, stress response and inflammatory response. In recent years, the study found that the cannabinoid system plays an important role in cognitive dysfunction. Objective To summarize the research of cannabinoid in cognitive dysfunction .Content Introduce POCD and the cannabinoid system, summarize the research of cannabinoid in cognitive dysfunction .Trend Hope to provide researchers with the latest information, and do something for the research of mechanism of POCD.