Background Neutrophils (polymorphonuclear leukocytes,PMNs) membrane surface antigens maybe associate with the occurrence, development and deterioration of imflammation. Objective To find out the underlying biology effect of the change of neutrophils surface antigens. Content During sepsis neutrophils three main functions(adhesion, chemotaxis and phagocytosis) are related to a variety of membrane surface antigens change, which were published in the recent researches. Trend With the development of the studies in the mechanism of neutrophil surface antigens changes, there would be some new direction to diagnose and cure septic patient.