Background Voltage dependent calcium channels(VDCCs ) are involved in the mechanism of occurrence and maintenance of pain, calcium channel antagonists show well analgesic effect.Objective Reviewe and summarize the analgesic effect and its mechanisms of main types of calcium channel antagonists.Content Neurons which can feel noxious stimuli distributed in dorsal root ganglia and spinal cord dorsal horn have a large number of VDCCs, can regulate depolarization-induced influx of Ca2+, thus affect the release of glutamate and substance P and other pain-related neurotransmitter. Calcium channel antagonists,such as ziconotide, have a clear analgesic effect and is not easy to form tolerance and cause respiratory depression, but the route of administration is limited,and with narrow therapeutic window. Trend The analgesic effects of calcium channel antagonists need more further research and discussion, in order to develop more convenient and safe drugs, and to provide more choices for the clinical use.