Sjogren's syndrome is a systemic autoimmune disease in which lymphatic cells destroy the exocrine glands,especially the salivary and lacrimal glands.The patient’s physical condition is generally poor and this disease is very complicated.A 53-year-old woman with Sjogren's syndrome received internal fixation to left femoral intertrochanteric fracture.We emphasized potassium supplement properative to improve the general situation ,avoided the factors which would injury the mucosa of tracheal and bronchial during intubation , introperative and postoperative monitored blood gas and electyolyte timely and applicated hydrocortisone to prevent cortisol crisis.All these measures helped the patient get over the operation successfully.