Ｏｂｊｅｃｔｉｖｅ　To compare the effect of multi-modal analgesia between dezocine and parecoxib sodium in Uighur patients undergoing gynecological laparotomy.　Methods　40 Uighur patients scheduled for elective gynecological laparotomy under general anesthesia， aged 25-55 years old， ASA Ⅰ-Ⅱ， were randomly divided into two groups， dezocine group（group A） and parecoxib sodium group （group B）. Dezocine 0.1 mg/kg and parecoxib sodium 40 mg were administered 30 min before the end of surgery respectively. The awakening time， Ramsay sedation score and brugg-rmann comfort scale（BCS） were recorded in both groups. Visual analogue scale（VAS）， rescue dose of fentanyl and its side effects were recorded using double blind method.　Results　The VAS of group A after extubation（2.4±2.2） and 24 h postoperative（3.2±2.4） were less than that of group B［（3.9±2.0），（4.3±2.1）］（P<0.05）， while the BCS of group A（2.0±0.4） was higher than that in group B（1.4±0.9）， with statistically significant difference（P<0.05）. The rescue dose of fentanyl in group A［（21±42） μg］ was significantly less（P<0.05） than that in group B［（47±40） μg］ .　Conclusions　The analgesia effect of dezocine 0.1 mg/kg intravenously is better than that of parecoxib sodium 40 mg for Uighur women undergoing gynecological laparotomy， especially in medium and major operation.