Objective: To observe the effect to patients of applying lukewarm lavage fluid in percutaneous nephrolithotomy. Method: 120 cases of undergoing percutaneous nephrolithotomy patients who received general anesthesia and endotracheal intubation Using a random number table, were randomly divided into three groups(40 cases in each group). Intravenous fluids and lavage group at room temperature used in Group I; Room temperature intravenous fluids and lukewarm lavage used in Group II; Lukewarm intravenous fluids lavage used in Group III. Patients in each group received general anesthesia with intubation at the same room temperature. Total volume of intravenous fluids and lavage during operation were recorded, as well as patient's temperature, mean arterial pressure and central venous pressure. The mean temperature during surgery and waking period, and the incidence of postoperative shivering were taken into statistical analysis. Results: Temperature in Group I and II during waking period significantly lower than (P<0.05) mean temperature during surgery 0.7℃.Group I patients recovery period average body temperature less than group II and III, the proportion of chills occur of postoperative,group I 57.5% ,group II 32.5%, group III 17.5% .Between the two groups statistically were significant different(P <0.05); The mean temperature during surgery and waking period in Group I, as well as the incidence of postoperative shivering, were significantly lower than (P<0.05) those in Group II and III. Conclusion: Lukewarm lavage can be effective in reducing the incidence of postoperative shivering in percutaneous nephrolithotomy, without side effect to patient's perioperative circulatory function.