Background Post extubation stridor (PES) resulting from laryngeal edema is a severe complication of endotracheal intubation, which exerts negative influences on patients’ prognosis. Objective In order to avoid PES and re-intubation, clinicians should extubate at a appropriate time, find those high risk patients of PES and take preventive measures. Content Clinicians can distinguish patients at high risk of PES using fiberoptic bronchoscopy, ultrasonography and cuff leakage test (CLT). The operative and anesthesia procedures should be standardized and corticosteroids can be used to prevent patients from developing PES. For those at high risk of PES, airway exchange catheter can be used at the time of extubation. Therapeutical measures include corticosteroids, nebulized epinephrine, helium administration and tracheostomy. Trend Clinicians should standardized procedures, detect high-risk patients and take preventive procedures to lower mortality.