【Abstract】 Objective To explore effect of dezocine preemptive analgesia on microvascular decompression for hemifacial spasm in anesthesia recovery period. Methods 32 patients, who underwent the microvascular decompression for hemifacial spasm, were randomly divided into experimental group (group I) and control group (groupⅡ) with 16 patients per group. In group I, intravenous injection of dezocine 5mg/2ml 30min before the end of surgery. In groupⅡ,intravenous injection of saline 2ml 30min before the end of surgery. Postoperative recovery time, pain visual analogue scale (VAS) 10min after extubation and pulling out laryngeal mask immediately riker agitation-sedation scale (RSS) were assessed. Mean arterial pressure (MAP), heart rate (HR) and oxygen saturation (SpO2) were observed at before anesthesia (T0, baseline), 5min before pulling out the laryngeal mask (T1), extracting the laryngeal mask immediately (T2) and 10min after pulling out the laryngeal mask (T3). Results There was no significant difference in postoperative recovery time between group I and groupⅡ (P >0.05). It showed significant difference between group I and groupⅡ in VAS 10min after extubation and pulling out laryngeal mask immediately RSS ( P <0.05). There was no significant difference in MAP and HR at T0 and T1 between group I and groupⅡ (P >0.05), it indicated significant difference at T2 and T3 between group I and groupⅡ (P <0.05), MAP and HR at T0 were compared with T2 and T3 ,which showed significant difference. There was no significant difference in SpO2 (P >0.05). The complications in recovery stage, such as respiratory depression, nausea and vomiting, chills and fever, weren’t observed in the two groups’ patients Conclusion Dezocine for preemptive analgesia can effectively relieve postoperative pain, reduce the incidence of pulling laryngeal mask immediately agitation and maintain hemodynamic stability in the recovery period of patients with microvascular decompression for hemifacial spasm.