背景 钙结合蛋白S100A8（ S100 calcium binding protein A8,S100A8）,是钙结合蛋白家族的重要成员，能与钙结合蛋白S100A9（ S100 calcium binding protein A9,S100A9）特异性结合形成异二聚体后行使生物学功能，研究表明其与炎症过程密切相关。钙结合蛋白S100A8通过参与核因子-кB（nuclear factor-κB，NF—кB）信号通路、还原型烟酰胺腺嘌呤二核苷酸氧化酶-活性氧信号通路（NADPH oxidase-active oxygen signal，NADPH-ROS）、丝裂原活化蛋白激酶（mitogen-activated protein kinases，MAPK）信号通路介导炎性细胞的趋化、参与急慢性炎症反应过程。目前研究发现钙结合蛋白S100A8特异抗体有中和钙结合蛋白S100A8的作用，能阻断钙结合蛋白S100A8的部分生物学功能。 目的 探讨钙结合蛋白S100A8在急性炎症信号传导通路中的作用。 内容 现就钙结合蛋白S100A8与急性炎症反应的相关性做一综述。 趋向 为急性炎症性疾病的早期诊断和防治提供新思路。
Background Calcium binding protein S100A8 is an important member of calcium binding protein which conduct biological functions after combine with calcium binding protein S100A9 to form a heterodimer specific and correlate with the process of inflammatory. Calcium binding protein S100A8 involved in mediated recruitment of inflammatory cells,acute and chronic inflammatory response through the NF-кB signaling pathway, NADPH-ROS signaling pathway, MAPK signaling pathway.Current study find that calcium binding protein S100A8-specific antibodies has the effect of neutralizing calcium binding protein S100A8 , block partly biological function of calcium binding protein S100A8. Objective To investigate the effect of calcium binding protein S100A8 in acute inflammatory signaling pathways. Content The article make a summary on the correlation of calcium-binding protein S100A8 and acute inflammatory response.make a summary on the correlation of calcium-binding protein S100A8 and acute inflammatory response.Trend To provide new ideas for early diagnosis and prevention of acute inflammatory disease.
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