Background Electroconvulsive therapy (ECT) is an effective treatment for major depression disorder. Some researches have founded that combination of low-dose ketamine and propofol in ECT can provide an antidepressant effects，which may due to the activity of glutamic acid receptor and gamma-aminobutyric acid receptor. AS the most important receptors in CNS, AMPA receptor and GABA receptor play vital roles in the antidepressant effects of ECT with low-dose ketamine and propofol. Objective In this paper, we talk about how AMPA receptor and GABA receptor affect the antidepressant effects of ECT with low-dose ketamine and propofol. Content Our review includes the research of depression cure situations by ECT; The research of ketamine and propofol applyed in ECT; The mechanism of AMPA receptor and GABA receptor contained in depression cured with ECT. Trend The mechanism of antidepressant effects of ECT with low-dose ketamine and propofol is complex, fully understanding the mechanisms will provide new thoughts in depression cure situations in cinical.