Abstract: Background:PTD-SOD is a new type of fusion protein which’s made by Genetic engineering. It’s really hot in recent years. Objective: Medical researchers will get knowledge about PTD-SOD and the study progress of it in cerebral ischemia and reperfusion injury from this article. Content: protein transduction domain (PTD),as a part of PTD-SOD structure,can take exogenous superoxide dismutase (SOD) into cells. This article will introduce the fusion protein PTD-SOD from the structure, preparation methods, activity and application in cerebral ischemia reperfusion injury and so on. Trend: This progress also can solve the problem of SOD to through the cell membrane as a macromolecular protein, and have great significance in the study of brain protection.
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