Background The perioperative period stress response is not conducive to the patient's postoperative recovery. It goes against the Fast Track Surgery (FTS), which is rapidly developing recently. Nutritional support is an important strategy of FTS, and there are already many clinical and basic studis which comfirm that perioperative amino acid infusion is an effective mean of nutritional support. Objective This review will discuss the influence of perioperative amino acids infusion to the body temperature and metabolism. Content Amino acid infusion alleviates hypothermia via nutrient induced thermogenesis (NIT), and can inhibit fat mobilization and muscle protein breakdown, promote protein synthesis, while accelerate the increase of blood glucose concentration. Trend It is an optimization strategy for FTS to explore appropriate time and dose of perioperative amino acids infusion.