Background:The acute lung injury/acute respiratory distress syndrome(ARDS) is a common clinical disorder characterised by injury to the alveolar epithelial and endothelial barriers of the lung, acute inflammation, and protein rich pulmonary oedema leading to acute respiratory failure. Its pathogenesis is complicated, it has not been fully elucidated so far. Content:Ventilator-induced lung injury and pulmonary edema refers to the process of applying ventilator jointly lead to pulmonary edema due to mechanical ventilation and many other factors of primary lung. It considered that the integrity of the alveolar membrane damage and permeability changes is the fundamental reason. The early manifestations of alveolar permeability increase, pulmonary edema and follow-up manifested as pulmonary infiltration of inflammatory cells and inflammatory mediators in hoarding. Adherin junction (AJ) and tight junction (TJ) are the important structures of maintenance of epithelial barrier and permeability, and the role of tight junction is more important. Tight junction protein includes Zo-1, Claudin and the latching protein (Occludin) and so on. Objective:In this article we do a review of research progress of tight junction protein occludin in acute lung injury. Trend:Realized the role of tight junction protein occludin in ventilation induced lung injury，then provided a theoretical basis for early prevention and treatment of ventilation induced pulmonary edema and lung injury in clinical.