Ｏｂｊｅｃｔｉｖｅ　To evaluate the efficacy of Coopdech bronchial blocker combined with a laryngeal mask airway Supreme for airway management in patients undergoing esophageal carinoma resection.　Methods　Sixty patients undegoing esophageal carcinoma resection were randomly divided into 3 groups （n=20）： double-lumen tube group （group DT）, Coopdech bronchial blocker combined with single-lumen tube group （group TC） and Coopdech bronchial blocker combined with a laryngeal mask airway Supreme group （group SC）. The fiberoptic bronchoscope was used to assist endotracheal tube positioning in both groups. The first attempt success rates of intubation, the intubation time, positioning time, the number of fiberoptic bronchoscopy attempts，degree of lung collapse, postoperative atelectasis, postoperative sore throat and hoarseness were recorded. Blood pressure （BP）, heart rate （HR） and bispectral index （BIS） were recorded before anesthesia（T0），immediately after intubation（T1） and at 1， 3 min and 5 min after intubation （T2-4）. Airway pressure（Paw） and end tidal carbon dioxide partial pressure（PETCO2） was recorded at two lung ventilation 10 min（T5） and 10 （T6）, 30（T7）, 60 min（T8） after one lung ventilation（OLV）.　Results　Compared to group DT, The intubation time and the positioning time was significantly shorter in group TC and group SC. Compared with T1, HR, BP and BIS significantly increased in group TC and group SC group at number of patients required for tube T2-4. Compared with group group DT, there was no significant difference in SP, DP, HR, BIS, the displacement, the number of fiberoptic bronchoscopy attempts and degree of lung collapse among the three groups. Paw was significantly higher during OLV at group DT than group SC. Incidences of postoperative sore throat and hoarseness were significantly lower in group SC（20%） compared to group DT（80%） and group TC（45%）.　Conclusions　The efficacy of the Coopdech bronchial blocker combined laryngeal mask airway Supreme is safe in patents undergoing esophageal carinoma resection.