Ｏｂｊｅｃｔｉｖｅ　To investigate the clinical effects of a Clinical small dose of dexmedetomidine（Dex） combined with dezocine in elderly patients with upper abdominal operation during recovery from general anesthesia.　Methods　Eighty ASA Ⅱor　Ⅲ patients of both sexes， aged ≥65 y， weighing 52 kg-71 kg，undergoing elective upper abdominal operationwere randomly divided into four groups with 20 patients each： Dex group（group A）， Dex+dezocine group（group B）， dezocine group（group C） and contorl group（group D）. Anesthesia was induced with iv injection of midazolam， fentanyl， proppfol and rocuronium， Dex 0.25 μg/kg was injected intravenously over 15 min starting from 30 min before the end of operation in group A， dezocine 0.1 mg/kg was injected intravenously in group B， dexmedetomidine 0.25 μg/kg was injected and then dezocine 0.1 mg/kg was injected intravenously in group C. While the equal volume of normal saline was administered instead in group D. The patients were sent to postanesthesia care unit（PACU） after extubation. Hemodynamic changes before treatment （T0）， extubation time （T1），and 5 min after extubation （T2） were observed， spontaneous breathing recovery time， wake-up time and extubation time were recorded， Ramsay scores and VRS scores and adverse reactions after surgery during PACU were also recorded.　Results　Mean artery pressure（MAP）［（90±13），（99±12），（113±15） mmHg（1 mmHg=0.133 kPa）］of patients in group B were decreased significantly than that of other three group at T1 and T2（P<0.05）. Heart rate（HR） and MAP of patients in group D at T1 and T2 was increased significantly than that of patients in group D at T0 （P<0.05）. Compared with group D， incidents of restlessness， chills and cardiovascular events was significantly decreased （P<0.05）　among the other 3 groups.　The adverse reaction rate in ｇroup B was lower than that of group A and group C （P<0.05）.　Wake-up time and extubation time ［（16.4±2.4）， （11.6±2.6） min）］ in group B were slightly longer than that of time ［（11.2±2.7），（8.7±2.5）　min）］ in group A（P<0.05）.　Compare with groupA and group C， surplus pulse O2（SpO2） of group B was decreased at T1（P<0.05）. Compare with VRS and Ramsay scores after extubation times of 5 min and 30 min in group B， VRS scores in group A and group C were decreased significantly，while Ramsay scores were increased （P<0.05）.　Conclusions　Thirty mins before the end of surgery， slow intravenous infusion of small doses of Dex or intravenous dezocine in elderly patients undergoing upper abdominal operation anesthesia is safe and effective， Dex combined with dezocine can provide more stable hemodynamics and good analgesia and sedation， decrease the adverse reactions from its usual ccurrence rate， but the anesthesia recovery time and extubation time were slightly longer， immediate tracheal extubation caused respiratory inhibition.