【摘要】 背景 使用阿片类药物停药后，可导致患者疼痛敏感性增加，即阿片类药物诱发的痛觉过敏（opioid-induced hyperalgesia， OIH），参与术后疼痛的组成。环氧化酶（cyclooxygenase， COX）抑制剂具有抗炎及抗痛觉过敏的作用，广泛用于术后镇痛治疗。 目的 了解COX抑制剂在防治OIH中的作用并进行归纳总结。 内容 COX抑制剂预防OIH的基础及临床研究现状。 趋向 COX抑制剂特别是COX?蛳2抑制剂可有效减轻OIH，其作用机制还需进一步研究。
【Ａｂｓｔｒａｃｔ】 Background Opioid-induced hyperalgesia（OIH） is defined as a state of nociceptive sensitization caused by exposure to opioids，which partially contributes to the postoperative pain. Cyclooxygenase（COX） inhibitors are widely used medications for postoperative pain control in clinic due to their anti-inflammatory and anti-hyperalgesia properties. Objective To review and summarize the roles of COX inhibitors in the prevention and treatment of OIH. Content This article reviews the latest basic and clinical research of COX inhibitors in the prevention and treatment of OIH. Trend COX inhibitors， especially COX-2 inhibitors can significantly attenuate OIH. However， further research is needed to dissect the mechanism of COX inhibitors in attenuating OIH.
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