背景 术后认知功能障碍（postoperative cognitive dysfunction， POCD）是麻醉手术后常见的神经系统并发症，尤其在老年人多见。脑内铁积聚是一些神经退行性病变的起始因素，通过诱发氧化应激损伤，引起神经元变性坏死。 目的 探讨铁积聚在POCD中的作用。 内容 描述脑内铁分布，铁代谢蛋白功能，铁积聚与神经退行性变的关系以及其在POCD中的研究进展。 趋向 铁积聚可能是引发POCD的重要机制，铁鳌合剂的神经保护作用有望为POCD的治疗提供新思路。
Background Postoperative cognitive dysfunction（POCD） is a common neurological complication after anesthesia and surgery， especially prevalent in the elderly. Iron accumulation in the brain is an initial cause of neurodegeneration， it gives rise to neuronal degeneration and necrosis by arousing oxidative stress. Objective This review aims to investigate the role of iron accumulation in POCD. Content The distribution of brain iron， iron metabolism protein function， the relationship of excessive iron levels in the brain and neurodegeneration， as well as the progress of iron accumulation in POCD are described in the article. Trend Iron accumulation may be an important mechanism of POCD， the neuroprotection of iron chelator is expected to provide new target for the management of POCD.
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