Objective To investigate anesthesia management of simultaneous coronary artery bypass grafting (CABG) and lung cancer operarion. Methods Eight patients with ASA grade Ⅱor Ⅲ, scheduled for elective simultaneous coronary artery bypass and lung resection, were retrospectively analyzed from November 2012 to September 2013 at the Shanghai Chest Hospital. Preoperative diagnosis included 3 cases of right lung tumour combined with coronary heart disease (CAD) and 5 cases of left lung tumour with CAD. Anesthesia management, intraoperaitive complications, treatments, and outcomes were recorded and analyzed. Results All patients discharged from hospital without severe perioperative complications. Double-lumen endobronchial tube in 5 cases and bronchial blocker in 2 cases were used for lung separation, and without Lung separation in 1 case. Compared with before CABG, Base excess (BE) decreased and blood glucose increased at time points of after CABG and lung resection (P<0.05 or 0.01), and lactic acid showed a increasing trand. Conclusions Circulation and airway management was complicated in patients with simultaneous CABG and lung resection, and homeostatic and oxygen supply and demand equilibrium were disturbed easily.