国际麻醉学与复苏杂志   2015, Issue (5): 6-6
    
酪氨酸激酶-信号转导和转录激活因子信号通路参与神经病理性疼痛的研究进展
崔珊珊, 柯剑娟, 冯晓波1()
1.13419598276
The progress of janus kinases-signal transducer and activators of transcription signaling pathway in neuropathic pain
 全文:
摘要：

背景　神经病理性疼痛（neuropathic pain， NP）是一种最常见的、最棘手的慢性疼痛之一。酪氨酸激酶?蛳信号转导和转录激活因子（janus kinases-signal transducer and activators of transcription， JAKs-STATs）信号通路是介导细胞反应的重要信号通路系统，近年有研究表明JAKs-STATs信号通路参与NP。　目的　探讨JAKs-STATs信号通路参与NP的机制。　内容　分别从JAKs-STATs信号通路生物学特性、JAKs-STATs信号通路对NP调节机制的研究现状进行综述。　趋向　为更好地治疗NP提供理论依据。
关键词： 酪氨酸激酶-信号转导和转录激活因子信号通路；　神经病理性疼痛；　星形胶质细胞
Abstract:

Background　Neuropathic pain（NP） is one of the most common and tricky chronic pain. Janus kinases-signal transducer and activators of transcription（JAKs-STATs） signaling pathway is an important signaling pathway in mediating cell reaction system. In recent years， studies have shown that JAKs-STATs signaling pathway is closely related to NP.　Objective　To explore the mechanisms of JAKs-STATs signaling pathway in NP.　Content　This article firstly reviewed the biological characteristics of JAKs-STATs signaling pathway； then reviewed the current studies about the regulating mechanism of JAKs-STATs signaling pathway in NP.　Trend　It provides a new theory basis for the treatment of NP.
Key words: Janus kinase-signal transducer and activator of transcription signaling pathway；　Neuropathic pain；　Astrocyte