背景 现有的药物对慢性疼痛的治疗效果不佳且副作用较大，因而需要寻找新的、安全有效的治疗方法。而最近研究发现，趋化因子及其受体在慢性疼痛的发生发展中起着重要的作用。 目的 综述趋化因子在慢性疼痛尤其是神经病理性疼痛中的作用机制。 内容 就趋化因子家族CC类亚家族参与疼痛调控的相关研究进行综述，阐述其在神经病理性疼痛发生发展中的可能作用机制。 趋向 越来越多的学者发现CC类亚家族参与神经病理性疼痛的发生发展，其有望成为临床上治疗慢性疼痛的一个新靶点。
Background The current treatment of chronic pain is almost accompanied by a poor response and the side effect is quite undesirable. But a recent study has found that the chemokines and their receptors play a crucial role in the induction and maintenance of chronic pain. Objective To investigate the mechanisms by which chemokines contribute to chronic pain， especially neuropathic pain. Content This review puts an emphasis on gathering and reorganizing information about the mechanisms of CC chemokines sub-family in neuropathic pain， which may be the most important chemokines in regulating nociception. Trend Chemokines and their receptors may become novel therapeutic targets and approaches for the treatment of chronic pain.
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