Abstract: Background α-amino-3-hydroxy-5-methyl-4-isoxazole-propionate(AMPA) receptor is one of the excitatory ionotropic glutamate receptors, the excitatory ionotropic glutamate receptors. Glutamate can bind to AMPA receptor and mediate postsynaptic currents, which enhances neuronal excitability and pain information upload, and finally causes hyperalgesia. Objective This review focuses on the role of AMPA receptor in remifentanil induced hyperalgesia. Content This review provided a comprehensive summary of the basic features, trafficking and function of AMPA receptor, as well as its roles in remifentanil induced hyperalgesia. Trend Targeting AMPA receptor may provide a new approach for the treatment of remifentanil induced hyperalgesia.
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