Ｏｂｊｅｃｔｉｖｅ　To evaluate the effect of droperidol pretreatment on postoperative pain and comfort in patients undergoing gynecologic laparoscopic surgery.　Methods　Forty-six female patients undergoing gynecologic laparoscopic surgery were divided into two groups randomly（n=23）： the patients were treated with droperidol intravenously（group D）， while patients were given with placebo as control（group C）. General characteristics of patients in two groups were recorded， including age， height， weight， operation time， postoperative recovery time， and endotracheal extubation time. Ramsay score and M-Aldrete score immediately and 30 min after extubation were recorded. The postoperative pain scores of all patients were recorded at the time point of 30 min， 1， 6 h and 24 h after endotracheal extubation by numerical rating scale（NRS）. Postoperative incidence of nausea and vomiting and other side effects were recorded.　Results　General characteristics of patients in both groups were similiar（P>0.05）. Compared with group C［（3.5±1.6）， （3.7±1.5）， （3.4±1.8）， （2.4±1.4）］， the NRS in group D［（1.4±1.3），（1.7±1.5）， （1.5±1.5）， （0.9±0.8）］ was significantly lower at 30 min and 1 h after endotracheal extubation and 6， 24 h after operation respectively（P<0.05）. Difference between the two groups was not statistically significant at each time point in mean arterial pressure and heart rate（P＞0.05）. There was no significant difference of Ramsay score and M-Aldrete score in both groups. The incidence of postoperative nausea and vomiting was significantly higher in group C（P<0.05）. There were no respiratory depression, mental disorders, extrapyramidal reactions and other side effects in the two groups. 　Conclusions　Droperidol pretreatment provides a significant analgesic benefit and makes patients undergoing gynecologic laparoscopic surgery comfortable.