【Abstract】 Objective: We aimed to evaluate the efficacy of dezocine in preventing sufentanil-induced cough during induction of general anesthesia. Methods: Two hundred and forty patients（ASA I~II）,aged 18~65,weighing 40~80kg, male or female, undergoing elective surgery were randomly divided into control group (group C) 、 dezocine group1 (group D1) and dezocine group 2 (group D2), 80 patients in each group. Patients in the control group and the study group(D1,D2) received 5ml 0.9% normal saline、dezocine at 0.05mg/kg and 0.1mg/kg 2 min prior to intravenous sufentanil (0.5 μg/kg).The incidence and severity of cough in patients were evaluated within 2 min after the injection of sufentanil in the anesthesia induction period. Result: No patient had cough in group D2, 35 patients in group C had cough(severity of cough:mild,11.3%;moderate,12.5%;severe,20%),and 32 patients in group D1 had cough(severity of cough:mild,13.8%;moderate,8.8%;severe,17.5%).The occurrence and reflex degree of cough in group D2 was significantly lower than that in group C and D1(P<0.01), while there was no significant difference between group C and group D1. Conclusion: The results of current study suggest that administration of Dezocine 0.1mg/kg may effectively prevent the sufentanil-induced bucking in our patients，and the hemodynamics were stale during general anesthesia induction.